Angelo Loukakis attended Fort Street High School, Sydney and in 1975 gained a Bachelor of Arts degree in English Literature from the University of New South Wales and, in 1976, a Diploma of Education from Sydney Teachers College. He has worked as a teacher of English as a second language, as a multicultural education project officer, as a welfare officer and as a freelance journalist for various newspapers including the Sydney Morning Herald and The National Times. In 1980 his film, Dancing, was awarded a prize for production at the Melbourne Film Festival. He also wrote a screenplay for another of his stories, Doherty. He was writer-in-residence for the Toe Truck Theatre Company of Sydney for four months specialising in theatre in education. He is the author of a children's book on Greeks in Australia and a travel book on Norfolk Island, Norfolk, an Island and Its People (1984).
In January 2010, Loukakis was appointed executive director of the Australian Society of Authors.