The two series of The Henderson Kids (produced two years apart) explore the changing circumstances of Steve and Tamara Henderson, as they first go to live with their uncle in a small seaside community after the hit-and-run death of their mother (series one) and then return to the city to live with their father (series two).

Each series had an over-arching story arc: in the first series, the 'kids' and their friends attempt to stop a predatory property developer, and in the second series, the 'kids' and their new gang stop a group of thieves who are targeting the Hendersons' father.

According to Moran, in his Guide to Australian TV Series, series one cost $3 million to produce over a six-month period, and series two cost $3.5 million to produce. Intended for a 7:30pm timeslot, series one was instead shown in the late afternoon. Series two reverted to a 7:30pm timeslot, as an attempt to capture some of the youth demographic of Hey Hey Its Saturday.