The Wayne Manifesto takes us into the world of twelve-year-old Wayne Wilson, showing us the world as Wayne would like it to be and the world as it really is. When his family move to their new home, Wayne wants nothing more than to fit in and keep out of the way of the school bully. He befriends the laid-back Squocka, the self-reliant Violet, and the young, energetic Rosie, and takes on his new life with enormous optimism.

The program has a strong magic-realism component in Wayne's active imagination and the way in which he uses this to manipulate the viewer's sense of his reality.