Deborah Cheetham has worked as a professional opera singer, director and producer of plays. In 1996, the Olympic Arts Festival commissioned Cheetham to write and perform a play, 'White Baptist Abba Fan' for the 1997 Festival of the Dreaming. Cheetham has performed in Australia and around the world. In 2000, Cheetam performed her commissioned piece: Dali Mana Gamarada, at the Sydney Olympics as a welcome to country during the Opening Ceremony.
In September 2011 the University of Melbourne, Faculty of the VCA and Music announced that Deborah Cheetham was appointed Head of the Wilin Centre for Indigenous Arts at the Faculty.