Jo Watson began working with Jonathan M. Shiff Productions in the late 1990s, when she was employed as a script coordinator and script editor for the children's science-fiction television series Thunderstone(1999). She followed this with a role as script editor on Cybergirl in 2001, as story consultant on Wicked Science (2006), and as story consultant on H2O: Just Add Water (2006), all Shiff productions. She also wrote the occasional script for these and other Shiff programs, including Pirate Islands (2003), Wicked Science (2004), and H2O: Just Add Water (2006).
In 2008, she worked as a script-writer on children's animated program Pixel Pinkie: produced by Blue Rocket Productions in association with the Nine Network, the program followed a young girl whose new mobile phone comes complete with a small, pink, accident-prone genie.
Since 2010, Watson has worked as a script-writer for long-running soap opera Neighbours.
A daily television drama series set in the fictional Melbourne suburb of Erinsborough, Neighbours chronicles the lives of the residents of Ramsay Street. The series initially revolved around three families: the Ramsays (at number 24 Ramsay Street), the Robinsons (at number 26), and the Clarkes (at number 28). The scope of the series has since broadened to include new Ramsay Street familes.