Samuel Genocchio was born in Melbourne and grew up in Sydney. He studied at the Australian Film Television and Radio School and then began work as a writer for the television program Neighbours. Genocchio worked as a freelancer in a range of creative arts roles, including director, writer and producer for film, television, theatre and events, but the majority of his work was as a screenwriter. Genocchio was co-founder of Short and Sweet, the largest short play festival in the world.
A daily television drama series set in the fictional Melbourne suburb of Erinsborough, Neighbours chronicles the lives of the residents of Ramsay Street. The series initially revolved around three families: the Ramsays (at number 24 Ramsay Street), the Robinsons (at number 26), and the Clarkes (at number 28). The scope of the series has since broadened to include new Ramsay Street familes.