Series One of East West 101 focuses on two men whose destinies are irrevocably intertwined. Malik is driven by a hunger for justice. He was twelve when a masked gunman held up the family shop. Malik refused to hand over the money and his father was subsequently shot and injured. He later joined the police force and has been looking for the shadowy figure who pulled the trigger. When he finally finds him, Malik's belief in the justice system is challenged by a powerful desire for revenge. As he hunts down the truth, it is revealed that one of his colleagues, Crowley, had a part to play in the original investigation. Crowley is a man whose vision has been blighted by pain and prejudice. His son, Paul, was found dead of an overdose on drugs sold to him by a Lebanese dealer. When the drug dealer who sold Paul the heroin is found murdered, Internal Affairs come asking questions.
In Season Two, East West 101 expands to seven episodes as the Major Crime Squad investigate crime and murder in all quarters of multicultural Sydney. But overarching all is the quest for Detective Zane Malik to find the truth behind a car bomb attack which kills two men. The Major Crime Squad form a joint task force with the NSO (National Security Organisation) to deal with the crime. There is paranoia in the city and fallout on the Muslim community. Malik knows that in order to stop the circle of hate, he must solve the crime. Was the bomb really an act of extremists, as the media suggest, or a sophisticated killing by a career criminal? Malik doggedly pursues the truth until he, too, becomes a target. Inspector Patricia Wright questions his motives but her vision is clouded by personal issues that she wants to keep hidden from the squad. Crime has touched her own family.
Season Three : The Hero's Journey. 'In [this]third season of East West 101, the Major Crime Squad investigates a 36 million dollar robbery in Australia and its connections to the murder of 17 people in Afghanistan. Is the robbery to fund an act of terror by military trained radicals, or the work of sophisticated criminals? For Detective Zane Malik the case has savage personal and professional ramifications. Malik is obstructed in his quest to find those responsible by the interference of newcomer Detective Neil Travis. Travis has fought in Iraq and his attitude and approach to the investigation cause conflict with Malik. In the hunt for an elusive foe, ultimately both men are forced to confront what makes a man a hero, or a coward...'
(Source: East West 101, SBS website)